Background: Despite the enormous benefits associated with contraceptive use, only a few sexually active married adults in developing countries like Nigeria use contraceptive methods, this situation is even worst in rural areas across Nigeria. This study examines the influence of myths on the use of contraceptive methods in Calabar South Local Government Area, Cross River State, Nigeria. Methods: Using the mixed approach, data were obtained from 600 respondents, using a multi-stage sampling technique which in this study entails the selection of community clusters, streets, villages, housing units and respondents through simple random and purposive sampling techniques. In the analysis and interpretation of study findings, descriptive statistics were employed, and qualitative data were analyzed using content analysis. Results: The study shows that fear of pregnancy-related complications and fear of infertility are significant determinants of contraceptive use in Calabar South LGA, Cross River State, Nigeria. Conclusion: The study, therefore, concludes that myths associated with contraceptive use are real and a strong factor that discourages most married adults from the use of contraceptive methods. In the light above, this study calls for a more in-depth, useful, effective and aggressive grassroots contraceptive awareness campaign targeted at all categories of individuals irrespective of their literacy level and financial status in the rural area.