Abstract: The pregnant women experience physiological changes to support fetal growth and development. During pregnancy sex steroids have effects on metabolic, synthetic, and excretory hepatic functions. Liver disease that occurs during pregnancy can present a challenge for health care providers.  Identification of physiological changes is important to differentiate physiological changes in liver during pregnancy from pathological causes of liver. The aim of study is to evaluate the change in serum level of routine LFTs (ALP, AST, ALT) during different trimester of normal pregnancy compared with a control group of non- pregnant women.

Methods: A total of 100 women were screened. Among 75 healthy pregnant women, 25 from each trimester and 25 non-pregnant women formed controls. Samples were collected from department of obstetrics and gynaecology attending for ANC at RIMS Ranchi. Serum sample was taken and assessed for routine liver function tests.

Results: Mean ALT level in patients of our socioeconomic environment is 26.48±6.729 IU/L for non-pregnant, and for pregnant women of 1st 2nd, and 3rd, trimester were 19.08±8.514, 40.48±10.922 and 31.30±13.86 IU/L respectively.

Mean AST level in patients of our socioeconomic is 29.36±4.493 IU/L for non-pregnant and for pregnant women of 1st, 2nd, and 3rd, trimester was 31.80±6.624, 41.96±10.50 and 50.12±15.914 IU/L respectively.

Mean ALP level in pt of our socioeconomics is 86.10±14.440 IU/L for non-pregnant and for pregnant women of 1st, 2nd, and 3rd, trimester are69.12±10.530, 76.92±23.48, and 196.12±49.938 Among these enzymes, serum ALP level raises more and especially during third trimester. Establishing upper normal level will be of much help for obstetrician in management of pregnancy related problem and differentiating physiological changes from pathological conditions such as hyperemesis gravidarum, intrahepatic cholestasis of pregnancy, acute fatty liver of pregnancy, pre-eclampsia, eclampsia and HELLP syndrome etc.